Adrienna Katalin Kékesi, PhD

associate professor

room: 5-203., phone: /8104 or /8110 ext.

Homepage of Reasearch Group of Proteomics:

Research interest

  • Proteomics
  • Dinamic changes in extracellular microenvironment of neurons under physiological and pharmacological influences

Selected publications

Bihátsiné K.E.,Brlik J.,Kékesi A.,Balla J. Zsírsavelegyek összetételének elválasztás és szarmazékképzés nélküli tömegspektrometriás vizsgalata. Magyar Kemiai Folyóirat,95, /3/,120-123 (1989)

G. Juhász, Zs. Emri, K. Kékesi, K. Pungor: Local perfusion of the thalamus with GABA increases sleep and induces long-lasting inhibition of somatosensory event-related potentials in cats, Neurosci. Letters, 103, 229-233, 1989, i.f. 2.806

G. Juhász, K. Kékesi, Zs. Emri, I. Soltész, V. Crunelli: Sleep-promoting action of excitatory amino acid antagonists: a different role for thalamic NMDA and non-NMDA receptors, Neurosci. Letters, 114, 333-338, 1990, i.f. 2.765

K. Pungor, M. Papp, K. Kékesi, G. Juhász: A novel effect of MPTP: the selective suppression of paradoxical sleep in cats, Brain Res. 525, 310-314, 1990, i.f. 2.719

G. Juhász, K.A. Kékesi, Zs. Emri, J. Ujszászi, P. Krogsgaard-Larsen, A. Schousboe: Sleep-promoting effect of a putative glial g-aminobutyric acid uptake blocker applied in the thalamus of cats, Eur. J. of Phar. 209, 131-133, 1991 i.f. 3.516

V. Crunelli, Zs. Emri, N. Leresche, K.A. Kékesi, I. Soltész, K. Toth, J. Turner, G. Juhász:   GABAb receptors in the ventrobasal thalamus assessed by in vivo and in vitro experiments, Pharmacol. Comm. 2: 113-116, 1992 i.f. -

K. Pungor, A. Hajnal, A.K. Kékesi, G. Juhász: Paradoxical sleep deprivatory effect of a single low dose of MPTP which did not produce dopaminergic cell loss, Exp. Brain Res. 95: 473-476, 1993 i. f. 2.409

R. Galambos, G. Juhász, A.K. Kékesi, G. Nyitrai, N. Szilágyi: Natural sleep modifies the rat electroretinogram, Proc. Natl. Acad. Sci. USA 91: 5153-5157, 1994 i.f. 10.667

G. Juhász, Zs. Emri, A.K. Kékesi, O. Salfay, V. Crunelli: Blockade of thalamic GABAb receptors decreases EEG synchronization, Neurosci Letters, 172:  155-158, 1994 i.f. 2.703

J. Kardos, T. Blandl, I. Kovács, K.A. Kékesi, A. Reichart, G. Nyitrai, Á. Dobolyi, G. Juhász: Use of ligands with low nanomolar affinity to the GABAB  receptor: The effect of CGP 55845A on the release of amino acids, Pharmacology Rev. Comm, 8: 153-157, 1996

I. Ábrahám, G. Juhász, K.A. Kékesi, K. Kovács: Effect of intrahippocampal dexamethasone on the levels of amino acid transmitters and neuronal excitability, Brain Res. 733: 56-63, 1996, i.f. 2.526

G.. Nyitrai, Zs. Emri, V. Crunelli, K. Kékesi, Á.. Dobolyi, G. Juhász: In vivo blockade of thalamic GABAb receptors increases excitatory amino acid levels, Eur. J. Pharmacol. 318: 295-300, 1996 i.f. 2.339

A.K. Kékesi, Á. Dobolyi, O. Salfay, G. Nyitrai, G. Juhász: Slow-wave-sleep is accompanied by release of certain amino acids in the thalamus of cats, NeuroReport 8: 1183-1186,1997 i.f. 2.262

P. Klivényi, A.K. Kékesi, G. Juhász, L.Vécsei: Amino acid concentrations in cerebrospinal fluid of patients with multiple sclerosis, Acta Neurol. Scand. 95: 96-98, 1997 i. f. 0.902

G. Juhász, K.A. Kékesi, G. Nyitrai, Á. Dobolyi, P. Krogsgaard Larssen, A. Schousboe: Differential effects of nipecotic acid and 4,5,6,7-tetrahydro-isoxazolo 4,5,-c-pyridin-3-ol on  extracellular g- aminobutyrate levels in rat thalamus, Eur. J. Pharmacol. 331: 139-144, 1997 i.f. 1.960

G. Nyitrai, A.K. Kékesi, Á. Dobolyi, K. Pungor, G. Juhász: Single low dose of MPTP decreases extracellular levels of noradrenaline and monoamine metabolites in the ventrobasal thalamus of the rats, Neurobiology, 5: 249-261, 1997 -

V. Varga, A. Kékesi, G. Juhász, B. Kocsis: Reduction of the extracellular level of glutamate in the median raphe nucleus associated with hippocampal theta activity in the anesthetized rat, Neurosci. 84, 1: 49-57,1998 i. f. 3.591

Ábrahám, G. Juhász, K.A. Kékesi, K. Kovács: Corticosterone peak is responsible for stress-induced elevation of glutamate in the hippocampus, Stress, 2: 171-181, 1998 i.f. -

Á. Dobolyi, A. Reichart, T. Szikra, A.K. Kékesi, T. Karancsi, P. Slégel, M. Palkovits, G. Juhász: Analysis of purine and pyrimidine bases, nucleosides and deoxynucleotides in brain microsamples (microdialysates and micropunches) and cerebrospinal fluid, Neurochem. Int., 32: 247-256, 1998 i. f. 1.781

G. Nyitrai, É. Szárics, I. Kovács, K.A. Kékesi, G. Juhász, J. Kardos: Effect of CGP 36742 on the extracellular level of neurotransmitter amino acids in the thalamus, Neurochem. Int. 34: 391-398, 1999 i.f. 2.175

Á. Dobolyi, T. Szikra, A.K. Kékesi, Zs. Kovács, G. Juhász: Uridine is released by depolarization and inhibits unit activity in the rat hippocampus, NeuroReport, 10: 3049-3053, 1999 i.f. 2.682

Á. Dobolyi, A Reichart, T. Szikra, G. Nyitrai, K.A. Kékesi, G. Juhász: Sustained depolarisation induces changes in the purine and pyrimidine nucleoside microenvironment of brain cells in rat, Neurochem. Int. 37 (1): 71-79, 2000 i.f. 2.662

K.A. Kékesi, N. Szilágyi, G. Nyitrai, Á. Dobolyi, N. Skuban, J. Kardos: Persistent depolarization and Glu uptake inhibition operate distinct osmoregulatory mechanisms in the mammalian brain, Neurochem. Int., 37, 171-178, 2000 i.f. 2.662

J. Pálhalmi, T. Szikra, A.K. Kékesi, A. Papp, G. Juhász: An in vivo eyecup preparation for the rat. J. of Neurosci Meth. 105: 167-174, 2001 i.f. 1.659

G. Nyitrai, K.A. Kékesi, N. Szilágyi, A. Papp, G. Juhász, J. Kardos: Neurotoxicity of Lindane and Picrotoxin: Neurochemical and Electrophysiological Correlates in the Rat Hippocampus In Vivo, Neurochem. Res. 27: 139-145, 2002 i.f. 1.672

G. Nyitrai, K.A. Kékesi, Zs. Emri, É. Szárics, G. Juhász J. Kardos: GABAB receptor antagonist CGP-36742 enhances somatostatin release in the rat hippocampus in vivo and in vitro, Eur. J. Pharmacol. 2003, 478(2-8) i.f. 2.352

SW. Hughes, M. Lőrincz, DW Cope, KL Blethyn, KA Kékesi, HR Parri, G. Juhász, V. Crunelli, Synchronized oscillations at alpha and theta frequencies in the lateral Geniculate Nucleus Neuron, 2004, 42(2): 253-268 i.f. 14.439

M. Jelitai, M. Anderova, K. Markó, KA. Kékesi, P. Koncz, E. Sykova, E. Madarász: Role of gamma-butyric acid in early neuronal development: Studies with an embryonic neuroectodermal stem cell clone, J. of Neurosci Res. 2004, 76(6): 801-811 i.f. 3.727

Slézia, A.K. Kékesi, T. Szikra, AM. Papp, K. Nagy, M. Szente, Zs. Maglóczky, TF. Freund, G. Juhász: Uridine release during aminopyridine-induced epilepsy Neurobiology of Disease,  16(3): 490-9, 2004 i.f. 4.389

Kovács Zs., Kékesi AK, Bobest M., Török T., Szilágyi N., Szikra T., Szepesi Zs., Nyilas R., Dobolyi Á., Palkovits M., Juhász G.: Post mortem degradation of nucleosides in the brain: comparison of human and rat brains for estimation of in vivo concentration of nucleosides J. Neurosci. Meth. 148(1):88-93, 2005 i.f. 1.894

P. Klivényi, K.A. Kékesi, Zs. Hartai, G. Juhász, L. Vécsei: Effects of mitochondrial toxins ont he brain amino acid concentrations Neurochem Res. 30(11):1421-7, 2005  imp. p. 2.218

P. Medveczky, J. Antal, A. Patthy, K. Kékesi, G. Juhász, L. Szilágyi, L. Gráf: Human trypsin 4 selectively cleaves myelin basic protein: does this brain protease play a role in the patomechanism of multiple sclerosis?  FEBS Letters 580(2):545-52, 2006  imp. p. 3.372

Zs. Kovács, K.A. Kékesi, I. Ábrahám, D. Székács, N. Király, E. Papp, I. Császár, É. Szegő, K. Barabás, M. Andrásfalvy, A. Erdei, T. Bártfai, G. Juhász: Facilitation of spike-wave discharge activity by LPS in WAG/Rij rats Neuroscience  140(2):732-42, 2006 imp. p. 3.427

G. Nyitrai, K.A. Kékesi, G. Juhász: Extracellular level of GABA and Glu: in vivo microdialysis-HPLC measurements Curr Top Med Chem 6(10):935-40, 2006 imp. p. 4.167

K.A. Kékesi, Zs. Kovács, N. Szilágyi, M. Bobest, T. Szikra, Á. Dobolyi, G. Juhász, M. Palkovits: Concentration of nucleosides and related compounds in cerebral and cerebellar cortical areas and white matters of the human brain, Cellular and Molecular Neurobiology 26 (4-6):831-42, 2006 imp. p. 0.959

B. Szenthe, A. Patthy, Z. Gáspári, A.K. Kékesi, L. Gráf, G. Pál: When the Surface Reports What Lies Beneath: Chimera Phage-Display Reveals that Surface-Core Interactions Cause Taxon-Specificity in the Pacifastin Protease Inhibitor Familiy, JMB, 370(1).63-79, 2007 imp.p. 4.89

T. Tauber, B. Berta, A. J. Székely, I Gyarmati, K. Kékesi, K. Márialigeti, E. M. Tóth:  Characterisation of community structure of bacteria in parallel mesophilic and thermophilic pilot scale anaerob sludge digesters Acta Microbiologica et Immunologica Hungarica 54(1): 47-55, 2007

S. W. Hughes, A. Errington, M.L. LQrincz, K. A. Kékesi, G. Juhász, G. Orbán, D.W. Cope, V. Crunelli: Novel lymodes of rhythmic burst firing at cognitively-relevant frequencies in thalamocortical neurons Brain Res. (in press)