Research themes

• Mechanisms of sleep-wake regulation
• Role of basal forebrain in the cortical activation
• Brain mechanisms and regulation of neuronal synchronization
• Connections of circadian rhythms with sleep

In our lab, we examine brain systems regulating sleep and wakefulness by complex methodology with special emphasize on the role of basal forebrain. We use combined electrophysiological and anatomical methods in anesthetized and freely-moving rats. These methods are frequently complemented by pharmacological and behavioral studies depending on the actual research project.

The main target of our research activity is the slow cortical rhythm (SCR). Examination of the SCR might help us to understand the functions of sleep as well as the mechanisms of information processing during sleep. SCR is generated by the cortex and can be recorded both in vitro and in vivo (during slow wave sleep and anesthesia). In our experiments, we would like to get insight into the neuronal mechanisms behind SCR, the operation of the rhythm-generator cortical circuits, and the connection of the SCR with information processing.

Our chronic lab enables the examination of the regulatory mechanisms of the circadian rhythms as well as the connections between circadian rhythms and sleep.